Reference

Glossary

Analytical and regulatory terminology only. Nothing here describes the effects or uses of any compound.

Amino acid analysis (AAA): A determination that hydrolyses a peptide into its constituent amino acids and quantifies them, used to establish net peptide content and to support composition.
Bacterial endotoxin test (LAL): A test for bacterial endotoxin using limulus amebocyte lysate or a recombinant equivalent, reported against a stated limit.
Certificate of analysis (COA): A document recording the results of specific analytical tests performed on a sample from a specific lot, on a stated date, by a stated laboratory.
Chain of custody: The documented record of who held a sample, and under what conditions, between its origin and its analysis.
Chromatographic purity: The main peak's share of total detected peak area in a chromatographic run, usually reported as a percentage.
Counterion: The ion paired with a charged peptide in its isolated salt form — trifluoroacetate and acetate are common.
Electrospray ionisation (ESI): An ionisation technique that transfers molecules from solution into the gas phase as ions, widely used for peptide mass spectrometry.
HPLC: High-performance liquid chromatography: a separation technique that resolves a mixture into components, commonly with UV detection for peptides.
ISO/IEC 17025: The international standard for the competence of testing and calibration laboratories, granted by an accreditation body for a defined scope of methods.
LC-MS: Liquid chromatography coupled to mass spectrometry: separation followed by mass measurement of the separated components.
Lot (batch): A quantity of material produced under conditions treated as uniform, identified so that test results on a sample can be attributed to the whole quantity.
Mass confirmation: Comparison of an observed molecular mass against the mass calculated from a compound's intended structure or sequence.
Net peptide content: The proportion of a preparation's mass that is peptide, as distinct from counterion, water and residual salts.
Research use only (RUO): A labelling statement indicating a product is not intended for use in humans. In US regulation the phrase is specifically defined for in vitro diagnostic products.
Intended use: The purpose for which a product is represented, assessed from the totality of the evidence about how it is presented and marketed.
Sterility testing: A compendial test for the recovery of viable microorganisms from a sample under defined culture conditions.
Third-party testing: Analysis performed by a laboratory with no commercial interest in the result, commissioned by and reported to a party independent of the seller.
Trifluoroacetate (TFA): A counterion frequently retained by peptides purified by preparative reversed-phase HPLC using trifluoroacetic acid as a mobile-phase modifier.