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Sermorelin · dosing reference

What dose information exists for Sermorelin?

A 29-amino acid GHRH fragment (GHRH 1-29 amide). Formerly FDA-approved as Geref for diagnostic pituitary evaluation and idiopathic growth hormone deficiency.

Published human study doses

Human study

Intervention parameters reported in individual published human studies. Each study stays separate; parameters are never aggregated across studies.

Human studyPrakash & Goa, BioDrugs (1999) — Review of GHRH 1-29
Population
Adults and children evaluated for growth hormone axis function
Route
Intravenous (diagnostic) or subcutaneous (maintenance)
Dose as published
Diagnostic: single IV bolus of 1 µg/kg. Therapeutic investigations: 30 µg/kg/day or fixed doses of 200–500 µg subcutaneous daily at bedtime
Frequency
Once daily at bedtime
Endpoint
Peak GH response and serum IGF-1 normalization

Community-reported ranges

Community

What people report discussing or doing in forums, on Reddit and in videos. Included only to show demand and reported practice — never as clinical evidence.

Community reportedhigh discussion volume

Typically discussed around 200–500 mcg (0.2–0.5 mg) administered subcutaneously once daily before sleep.

  • Preserved endogenous somatostatin negative feedback limits hyper-somatotropism compared to exogenous recombinant human growth hormone (rhGH).
Reddit r/Peptides · Anti-aging clinic publications · Last checked 22 September 2026

Community reports describe what people say they are doing. They are not equivalent to clinical evidence, and discussion volume says nothing about whether a practice is safe, effective or even real.

Why community reports are shown at all

People search for dose information before they search for anything else in this sector. Where discussion is widespread, pretending it does not exist helps nobody. Therapept reports the discussion — its rough shape, how common it is, and where it happens — while keeping it visibly separate from every other kind of source. Community reports describe what people say they are doing. They are not equivalent to clinical evidence.

Last reviewed 22 September 2026 · Compiled by Therapept Editorial · How these records are built