- Population
- Adults and children evaluated for growth hormone axis function
- Route
- Intravenous (diagnostic) or subcutaneous (maintenance)
- Dose as published
- Diagnostic: single IV bolus of 1 µg/kg. Therapeutic investigations: 30 µg/kg/day or fixed doses of 200–500 µg subcutaneous daily at bedtime
- Frequency
- Once daily at bedtime
- Endpoint
- Peak GH response and serum IGF-1 normalization
Sermorelin · dosing reference
What dose information exists for Sermorelin?
A 29-amino acid GHRH fragment (GHRH 1-29 amide). Formerly FDA-approved as Geref for diagnostic pituitary evaluation and idiopathic growth hormone deficiency.
Published human study doses
Human studyIntervention parameters reported in individual published human studies. Each study stays separate; parameters are never aggregated across studies.
Community-reported ranges
CommunityWhat people report discussing or doing in forums, on Reddit and in videos. Included only to show demand and reported practice — never as clinical evidence.
Typically discussed around 200–500 mcg (0.2–0.5 mg) administered subcutaneously once daily before sleep.
- Preserved endogenous somatostatin negative feedback limits hyper-somatotropism compared to exogenous recombinant human growth hormone (rhGH).
Community reports describe what people say they are doing. They are not equivalent to clinical evidence, and discussion volume says nothing about whether a practice is safe, effective or even real.
Why community reports are shown at all
People search for dose information before they search for anything else in this sector. Where discussion is widespread, pretending it does not exist helps nobody. Therapept reports the discussion — its rough shape, how common it is, and where it happens — while keeping it visibly separate from every other kind of source. Community reports describe what people say they are doing. They are not equivalent to clinical evidence.
Last reviewed 22 September 2026 · Compiled by Therapept Editorial · How these records are built
