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GHK-Cu · dosing reference

What dose information exists for GHK-Cu?

A naturally occurring copper tripeptide (glycyl-L-histidyl-L-lysine:copper). Primarily studied in topical dermatological formulations and animal tissue regeneration models.

Published human study doses

Human study

Intervention parameters reported in individual published human studies. Each study stays separate; parameters are never aggregated across studies.

Human studyPickart et al., International Journal of Molecular Sciences (2018)
Population
Human facial skin explants and clinical topical trials
Route
Topical dermal application
Dose as published
Topical application of 0.5% to 2.0% GHK-Cu cream/serum formulations
Frequency
Once or twice daily
Endpoint
Collagen synthesis, skin elasticity, reduction in fine lines and wrinkle depth

Community-reported ranges

Community

What people report discussing or doing in forums, on Reddit and in videos. Included only to show demand and reported practice — never as clinical evidence.

Community reportedhigh discussion volume

Topical: 1–3% creams and solutions. Injectable (subcutaneous): discussed widely as 1–2 mg daily, frequently noting significant injection-site stinging or post-injection soreness.

  • Injectable GHK-Cu has no approved human formulation or large-scale clinical trials; systemic copper toxicity and local tissue irritation remain clinical concerns with high-dose parenteral administration.
Reddit r/Peptides · Skincare forums · Last checked 22 September 2026

Community reports describe what people say they are doing. They are not equivalent to clinical evidence, and discussion volume says nothing about whether a practice is safe, effective or even real.

Why community reports are shown at all

People search for dose information before they search for anything else in this sector. Where discussion is widespread, pretending it does not exist helps nobody. Therapept reports the discussion — its rough shape, how common it is, and where it happens — while keeping it visibly separate from every other kind of source. Community reports describe what people say they are doing. They are not equivalent to clinical evidence.

Last reviewed 22 September 2026 · Compiled by Therapept Editorial · How these records are built