- Population
- Human facial skin explants and clinical topical trials
- Route
- Topical dermal application
- Dose as published
- Topical application of 0.5% to 2.0% GHK-Cu cream/serum formulations
- Frequency
- Once or twice daily
- Endpoint
- Collagen synthesis, skin elasticity, reduction in fine lines and wrinkle depth
GHK-Cu · dosing reference
What dose information exists for GHK-Cu?
A naturally occurring copper tripeptide (glycyl-L-histidyl-L-lysine:copper). Primarily studied in topical dermatological formulations and animal tissue regeneration models.
Published human study doses
Human studyIntervention parameters reported in individual published human studies. Each study stays separate; parameters are never aggregated across studies.
Community-reported ranges
CommunityWhat people report discussing or doing in forums, on Reddit and in videos. Included only to show demand and reported practice — never as clinical evidence.
Topical: 1–3% creams and solutions. Injectable (subcutaneous): discussed widely as 1–2 mg daily, frequently noting significant injection-site stinging or post-injection soreness.
- Injectable GHK-Cu has no approved human formulation or large-scale clinical trials; systemic copper toxicity and local tissue irritation remain clinical concerns with high-dose parenteral administration.
Community reports describe what people say they are doing. They are not equivalent to clinical evidence, and discussion volume says nothing about whether a practice is safe, effective or even real.
Why community reports are shown at all
People search for dose information before they search for anything else in this sector. Where discussion is widespread, pretending it does not exist helps nobody. Therapept reports the discussion — its rough shape, how common it is, and where it happens — while keeping it visibly separate from every other kind of source. Community reports describe what people say they are doing. They are not equivalent to clinical evidence.
Last reviewed 22 September 2026 · Compiled by Therapept Editorial · How these records are built
