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Semaglutide · dosing reference

What dose information exists for Semaglutide?

An approved drug with labelled schedules. Unapproved GLP-1 products are a separate regulatory matter and their contents are not the labelled drug.

Official product dosing

Official

Approved indication, route, dose, frequency and titration, sourced only from the FDA label, DailyMed or the manufacturer's prescribing information.

Official labelWEGOVY (semaglutide) injection
Approved indication
Chronic weight management in adults with obesity or overweight with at least one weight-related comorbidity, and in paediatric patients 12+ with obesity, per the label.
Route
Subcutaneous injection once weekly
Dose
Maintenance 2.4 mg once weekly after label-defined escalation from 0.25 mg.
Frequency
Once weekly
Titration
0.25 mg weekly for 4 weeks → 0.5 mg → 1 mg → 1.7 mg → 2.4 mg, per the label's escalation steps.

Published human study doses

Human study

Intervention parameters reported in individual published human studies. Each study stays separate; parameters are never aggregated across studies.

Human studyWilding et al., NEJM (2021) — STEP 1
Population
Adults with overweight or obesity without diabetes (n = 1,961)
Route
Subcutaneous
Dose as published
Once-weekly subcutaneous semaglutide 2.4 mg
Frequency
Once weekly
Duration
68 weeks
Endpoint
Percentage change in body weight; weight reduction of at least 5%

Why community reports are shown at all

People search for dose information before they search for anything else in this sector. Where discussion is widespread, pretending it does not exist helps nobody. Therapept reports the discussion — its rough shape, how common it is, and where it happens — while keeping it visibly separate from every other kind of source. Community reports describe what people say they are doing. They are not equivalent to clinical evidence.

Last reviewed 17 September 2026 · Compiled by Therapept Editorial · How these records are built