- Approved indication
- Chronic weight management in adults with obesity or overweight with at least one weight-related comorbidity, and in paediatric patients 12+ with obesity, per the label.
- Route
- Subcutaneous injection once weekly
- Dose
- Maintenance 2.4 mg once weekly after label-defined escalation from 0.25 mg.
- Frequency
- Once weekly
- Titration
- 0.25 mg weekly for 4 weeks → 0.5 mg → 1 mg → 1.7 mg → 2.4 mg, per the label's escalation steps.
Semaglutide · dosing reference
What dose information exists for Semaglutide?
An approved drug with labelled schedules. Unapproved GLP-1 products are a separate regulatory matter and their contents are not the labelled drug.
Official product dosing
OfficialApproved indication, route, dose, frequency and titration, sourced only from the FDA label, DailyMed or the manufacturer's prescribing information.
Published human study doses
Human studyIntervention parameters reported in individual published human studies. Each study stays separate; parameters are never aggregated across studies.
- Population
- Adults with overweight or obesity without diabetes (n = 1,961)
- Route
- Subcutaneous
- Dose as published
- Once-weekly subcutaneous semaglutide 2.4 mg
- Frequency
- Once weekly
- Duration
- 68 weeks
- Endpoint
- Percentage change in body weight; weight reduction of at least 5%
Why community reports are shown at all
People search for dose information before they search for anything else in this sector. Where discussion is widespread, pretending it does not exist helps nobody. Therapept reports the discussion — its rough shape, how common it is, and where it happens — while keeping it visibly separate from every other kind of source. Community reports describe what people say they are doing. They are not equivalent to clinical evidence.
Last reviewed 17 September 2026 · Compiled by Therapept Editorial · How these records are built
