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Compare peptides

Two to four compounds, field by field: identity, United States regulatory status, and what kinds of documents are on file. The table records differences. It does not rank them.

No winner, no score, no recommendation. Counts describe how many documents of each kind Therapept has indexed — not how well a compound works, and not how much has been published overall.

Link to this comparison: /compare?peptides=semaglutide,tirzepatide,bremelanotide

Side-by-side comparison of Semaglutide, Tirzepatide, Bremelanotide
SemaglutideTirzepatideBremelanotide
Identity
ClassGLP-1 receptor agonist (acylated GLP-1 analogue)Dual GIP and GLP-1 receptor agonistCyclic heptapeptide melanocortin receptor agonist
Also listed asOzempic, Wegovy, Rybelsus, NN9535Mounjaro, Zepbound, LY3298176PT-141, Vyleesi
Molecular formulaC187H291N45O59C225H348N48O68C50H68N14O10
Molecular weight4114 g/mol4813.53 Da (FDA label); 4813 g/mol (PubChem)1025.2 g/mol
CAS910463-68-22023788-19-2189691-06-3
PubChem CID568433311565883249941379
Sequence lengthDescribed structurally, not as a residue listDescribed structurally, not as a residue listDescribed structurally, not as a residue list
Data caveatNone recordedPubChem carries several duplicate deposits named “Tirzepatide” with identical CAS and formula. Full caveatBremelanotide is the C-terminal free acid; melanotan II is the amide. Full caveat
United States regulatory status
StatusFDA-approved drug substanceFDA-approved drug substanceFDA-approved drug substance
FDA applicationNDA 209637 (Ozempic), NDA 213051 (Rybelsus), NDA 215256 (Wegovy)NDA 215866 (Mounjaro), NDA 217806 (Zepbound)NDA 210557 (VYLEESI)
CompoundingSubject of FDA communications on GLP-1 compounding following resolution of the shortage.Subject of FDA communications on GLP-1 compounding following resolution of the shortage.No FDA compounding entry recorded
WADANot named in this recordNot named in this recordNot named in this record
Evidence on file
Records
4
3
2
Human-interventional records221
Human-observational records000
Animal records000
In-vitro records000
Reviews000
Regulatory documents211
Earliest indexed201620212019
Latest indexed202620232019
RecordsOpen evidence fileOpen evidence fileOpen evidence file

Every identity and regulatory value above is taken from the compound’s record, where its sources are listed. Evidence counts are derived from the published evidence file at build time. A missing class means no document of that kind is indexed — not that none exists.