Reference
Compare peptides
Two to four compounds, field by field: identity, United States regulatory status, and what kinds of documents are on file. The table records differences. It does not rank them.
No winner, no score, no recommendation. Counts describe how many documents of each kind Therapept has indexed — not how well a compound works, and not how much has been published overall.
Link to this comparison: /compare?peptides=afamelanotide,melanotan-ii
| Afamelanotide | Melanotan II | |
|---|---|---|
| Identity | ||
| Class | Linear 13-residue α-MSH analogue; melanocortin 1 receptor (MC1-R) agonist | Cyclic heptapeptide; non-selective melanocortin receptor agonist (alpha-MSH analogue) |
| Also listed as | Scenesse, Melanotan I, NDP-α-MSH, CUV-1647 | MT-II, MTII |
| Molecular formula | C78H111N21O19 | C50H69N15O9 |
| Molecular weight | 1646.85 (anhydrous free base, FDA label) | 1024.2 g/mol |
| CAS | 75921-69-6 | 121062-08-6 |
| PubChem CID | 16197727 | 92432 |
| Sequence length | Described structurally, not as a residue list | Described structurally, not as a residue list |
| Data caveat | “Melanotan” is used commercially for both this 13-residue linear peptide and for melanotan II, a 7-residue cyclic peptide. Full caveat | Melanotan II is the C-terminal amide; bremelanotide (PT-141) is the corresponding free acid. Full caveat |
| United States regulatory status | ||
| Status | FDA-approved drug substance | No FDA-approved product |
| FDA application | NDA 210797 (SCENESSE) | None recorded |
| Compounding | No FDA compounding entry recorded | FDA bulk-substance nomination withdrawn; safety concerns remain published. |
| WADA | Not named in this record | Not named in this record |
| Evidence on file | ||
| Records | 0 | 3 |
| Human-interventional records | 0 | 1 |
| Human-observational records | 0 | 0 |
| Animal records | 0 | 0 |
| In-vitro records | 0 | 0 |
| Reviews | 0 | 1 |
| Regulatory documents | 0 | 1 |
| Earliest indexed | Not recorded | 1996 |
| Latest indexed | Not recorded | 2026 |
| Records | Open evidence file | Open evidence file |
Every identity and regulatory value above is taken from the compound’s record, where its sources are listed. Evidence counts are derived from the published evidence file at build time. A missing class means no document of that kind is indexed — not that none exists.